Calcium electroporation of esophageal cancer induces gene expression changes: a sub-study of a phase I clinical trial.

ABSTRACT:

Purpose

In this study, we aim to investigate gene expression changes in tumor samples obtained from patients with esophageal cancer treated with calcium electroporation. Previously, local treatment with calcium electroporation has been shown to induce gene expression alterations, potentially contributing to a more tumor-hostile microenvironment.

Methods

In this sub-study of a phase I clinical trial, we included five patients with esophageal cancer treated with calcium electroporation. We compared cancer-associated gene expression patterns in tumor samples before and after treatment. Furthermore, we used linear support vector regression to predict the cellular composition of tumor samples.

Results

Using differential expression analysis, we identified the downregulation

SUBMITTER: Egeland C 

PROVIDER: S-EPMC10620256 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature