Mood swings are causally associated with intracranial aneurysm subarachnoid hemorrhage: A Mendelian randomization study.

ABSTRACT:

Background

Mood swings have been observed in patients with intracranial aneurysm (IA), but it is still unknown whether mood swings can affect IA.

Aim

To explore the causal association between mood swings or experiencing mood swings and IA through a two-sample Mendelian randomization (MR) study.

Methods

Summary-level statistics of mood swings, experiencing mood swings, IA, aneurysm-associated subarachnoid hemorrhage (aSAH), and non-ruptured IA (uIA) were collected from the genome-wide association study. Two-sample MR and various sensitivity analyses were employed to explore the causal association between mood swings or experiencing mood swings and IA, or aSAH, or uIA. The inverse-variance weighted method was used as the primary method.

Results

Genetically determ

SUBMITTER: Peng K 

PROVIDER: S-EPMC10636415 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature