Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study.

ABSTRACT:

Objective

To investigate the link between genetic variants associated with plasma homocysteine levels and risk of intracranial aneurysm (IA) using two-sample Mendelian randomization.

Methods

We used single-nucleotide polymorphisms associated with human plasma homocysteine levels as instrumental variables for the primary analysis in a genome-wide association study of 44,147 subjects of European ancestry. Summary-level statistics were obtained for 79,429 individuals, including 7,495 IA cases and 71,934 controls. To enhance validity, five different Mendelian randomization methods (MR-Egger, weighted median, inverse variance weighted, simple mode, and weighted mode) were used for the analyses.

Results

The inverse variance weighted analysis method produced P-values

SUBMITTER: Ma C 

PROVIDER: S-EPMC9554923 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature