Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response.

ABSTRACT: Understanding changes in pathogen behavior (e.g. increased virulence, a shift in transmission channel) is critical for the public health management of emerging infectious diseases. Genome degradation via gene depletion or inactivation is recognized as a pathoadaptive feature of the pathogen evolving with the host. However, little is known about the exact role of genome degradation in affecting pathogenic behavior, and the underlying molecular detail has yet to be examined. Using large-scale global avian-restricted Salmonella genomes spanning more than a century, we projected the genetic diversity of Salmonella Pullorum (bvSP) by showing increasingly antimicrobial-resistant ST92 prevalent in Chinese flocks. The phylogenomic analysis identified three lineages in bvSP, with an e

SUBMITTER: Zhou X 

PROVIDER: S-EPMC10642762 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature