Parietal stimulation reverses age-related decline in exploration, learning, and decision-making.
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ABSTRACT:
SUBMITTER: Hwang EJ
PROVIDER: S-EPMC10642975 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
Parietal stimulation reverses age-related decline in exploration, learning, and decision-making.
Hwang Eun Jung EJ Korde Sayli S Han Ying Y Sambangi Jaydeep J Lian Bowen B Owusu-Ofori Ama A Diasamidze Megi M Wong Lea M LM Pickering Nadine N Begin Sam S
bioRxiv : the preprint server for biology 20231023
Aging can compromise decision-making and learning, potentially due to reduced exploratory behaviors crucial for novel problem-solving. We posit that invigorating exploration could mitigate these declines. Supporting this hypothesis, we found that older mice mirrored human aging, displaying less exploration and learning during decision-making, but optogenetic stimulation of their posterior parietal cortex boosted initial exploration, subsequently improving learning. Thus, enhancing exploration-dr ...[more]
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