Effect of acute altitude exposure on physiological parameters and glucose metabolism in healthy lowland Peruvians.

ABSTRACT:

Background

High altitude exposure triggers a series of physiological changes to maintain homeostasis. Although longer-term (days to years) acclimatization processes are well studied, less is known about the physiological changes upon rapid ascent. We took advantage of Peru's geography to measure the first physiological changes following rapid transport from a low to a high-altitude environment among lowlanders.

Methods

Blood glucose, insulin, C-peptide, and salivary cortisol among healthy lowland Peruvians were measured before and after glucose ingestion at 40 m and upon arrival at 3470 m. Resting heart rate, blood oxygen saturation, and blood pressure were also monitored.

Results

At high altitude, we find a significant ( p<0.05) increase in heart rate and a de

SUBMITTER: Fernandez-Rodriguez LJ 

PROVIDER: S-EPMC10654490 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature