Differentiation of stable kidney function versus progressive dysfunction in dogs.

ABSTRACT:

Background

Circulating creatinine and symmetric dimethylarginine (SDMA) are biomarkers of kidney function that have been used variously to define stable vs progressive chronic kidney disease (CKD). Slope monitoring of inverse biomarker values (creatinine^-1 or SDMA^-1 ) has shown promise, but quantitative criteria to distinguish stable vs progressive CKD using this approach are lacking.

Objective

Assessment of creatinine^-1 and SDMA^-1 slope cutoffs to distinguish stable vs progressive CKD.

Animals

One hundred ten clinically healthy university staff-owned dogs and 29 male colony dogs with progressive X-linked hereditary nephropathy (XLHN).

Methods

Retrospective analysis combining 2 prospective observational studies, 1 tra

SUBMITTER: Cowgill LD 

PROVIDER: S-EPMC10658543 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature