Combined genomic-proteomic approach in the identification of Campylobacter coli amoxicillin-clavulanic acid resistance mechanism in clinical isolates.

ABSTRACT:

Introduction

Aminopenicillins resistance among Campylobacter jejuni and Campylobacter coli strains is associated with a single mutation in the promoting region of a chromosomal beta-lactamase bla_OXA61, allowing its expression. Clavulanic acid is used to restore aminopenicillins activity in case of bla_OXA61 expression and has also an inherent antimicrobial activity over Campylobacter spp. Resistance to amoxicillin-clavulanic acid is therefore extremely rare among these species: only 0.1% of all Campylobacter spp. analyzed in the French National Reference Center these last years (2017-2022).

Material and methods

Whole genome sequencing with bioinformatic resistance identification combined with mass spectrometry (M

SUBMITTER: Deforet F 

PROVIDER: S-EPMC10666280 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature