The bidirectional effects between cognitive ability and brain morphology: A life course Mendelian randomization analysis.

ABSTRACT:

Introduction

Little is understood about the dynamic interplay between brain morphology and cognitive ability across the life course. Additionally, most existing research has focused on global morphology measures such as estimated total intracranial volume, mean thickness, and total surface area.

Methods

Mendelian randomization was used to estimate the bidirectional effects between cognitive ability, global and regional measures of cortical thickness and surface area, estimated total intracranial volume, total white matter, and the volume of subcortical structures (N=37,864). Analyses were stratified for developmental periods (childhood, early adulthood, mid-to-late adulthood; age range: 8-81 years).

Results

The earliest effects were observed in childhood and early adu

SUBMITTER: Korologou-Linden R 

PROVIDER: S-EPMC10680890 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature