Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease.

ABSTRACT:

Importance

Neuropsychiatric symptoms are commonly encountered and are highly debilitating in patients with Alzheimer disease. Understanding their underpinnings has implications for identifying biomarkers and treatment for these symptoms.

Objective

To evaluate whether glial markers are associated with neuropsychiatric symptoms in individuals across the Alzheimer disease continuum.

Design, setting, and participants

This cross-sectional study was conducted from January to June 2023, leveraging data from the Translational Biomarkers in Aging and Dementia cohort at McGill University, Canada. Recruitment was based on referrals of individuals from the community or from outpatient clinics. Exclusion criteria included active substance abuse, major surgery, recent head trauma,

SUBMITTER: Schaffer Aguzzoli C 

PROVIDER: S-EPMC10682836 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature