Natural History of Pediatric Patients With Crohn's Disease Treated With Mesalamine Therapy.

ABSTRACT:

Background

5-aminosalicylates (5-ASA) are used to treat mild to moderate ulcerative colitis. Despite their lack of efficacy in Crohn disease (CD), they are still used in real-world practice. Additionally, when patients have progressive disease, they may escalate to biologic therapy, at which time 5-ASA may or may not be discontinued.

Objectives

The aim of this study is to assess the clinical outcomes of patients started on 5-ASA for the treatment of pediatric CD. The secondary aims were to evaluate the outcomes of those who continue 5-ASA to those who discontinue 5-ASA upon biologic escalation.

Methods

We performed a single-center retrospective chart review of pediatric CD patients from 2010 to 2019 who were initially treated with 5-ASA. Demographics, medication and l

SUBMITTER: Young DD 

PROVIDER: S-EPMC10684219 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature