Distilling causality between physical activity traits and obesity via Mendelian randomization.

ABSTRACT:

Background

Whether obesity is a cause or consequence of low physical activity levels and more sedentary time has not yet been fully elucidated. Better instrumental variables and a more thorough consideration of potential confounding variables that may influence the causal inference between physical activity and obesity are needed.

Methods

Leveraging results from our recent genome-wide association study for leisure time moderate-to-vigorous intensity (MV) physical activity and screen time, we here disentangle the causal relationships between physical activity, sedentary behavior, education-defined by years of schooling-and body mass index (BMI), using multiple univariable and multivariable Mendelian Randomization (MR) approaches.

Results

Univariable MR analyses suggest

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10689836 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature