Causality between Sarcopenia and Depression: A Bidirectional Mendelian Randomization Study.

ABSTRACT:

Background

Numerous observational studies have suggested a correlation between sarcopenia and depression, but the nature of this relationship requires further investigation.

Methods

This study employed bidirectional Mendelian randomization to explore this connection. Data from genome-wide association studies were used, encompassing measures of sarcopenia and mental factors, including depression and emotional states. The initial analysis concentrated on the impact of depression on sarcopenia, and then it examined the reverse relationship. The same methodology was applied to emotional data for validation.

Results

The results indicated a reciprocal causation between sarcopenia and depression, even when emotional state data were considered. Various emotions can impact sar

SUBMITTER: Li Y 

PROVIDER: S-EPMC11319753 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature