Plasma and cerebrospinal fluid proteomic signatures of acutely sleep-deprived humans: an exploratory study.

ABSTRACT:

Study objectives

Acute sleep deprivation affects both central and peripheral biological processes. Prior research has mainly focused on specific proteins or biological pathways that are dysregulated in the setting of sustained wakefulness. This exploratory study aimed to provide a comprehensive view of the biological processes and proteins impacted by acute sleep deprivation in both plasma and cerebrospinal fluid (CSF).

Methods

We collected plasma and CSF from human participants during one night of sleep deprivation and controlled normal sleep conditions. One thousand and three hundred proteins were measured at hour 0 and hour 24 using a high-scale aptamer-based proteomics platform (SOMAscan) and a systematic biological database tool (Metascape) was used to reveal altered bi

SUBMITTER: Vaquer-Alicea A 

PROVIDER: S-EPMC10691441 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature