APOE genotypes modify the obesity paradox in dementia.

ABSTRACT:

Background

While obesity in midlife is a risk factor for dementia, several studies suggested that obesity also protected against dementia, hence so-called obesity paradox. The current study aims to address the relationship between apolipoprotein E (APOE) genotype and obesity in dementia.

Methods

Clinical and neuropathological records of the National Alzheimer's Coordinating Center (NACC) in the USA, which longitudinally followed approximately 20 000 subjects with different cognitive statues, APOE genotype and obesity states, were reviewed.

Results

Obesity was associated with cognitive decline in early elderly cognitively normal individuals without APOE4, especially those with APOE2. Neuropathological analyses adjusted for dementia status sh

SUBMITTER: Shinohara M 

PROVIDER: S-EPMC10695687 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature