STUN: forward-time simulation on TUnable fitNess landscapes in recombining populations.

ABSTRACT:

Motivation

Understanding the population genetics of complex polygenic traits during adaptation is challenging.

Results

Here, we implement a forward-in-time population-genetic simulator (STUN) based on Wright-Fisher dynamics. STUN is a flexible and user-friendly software package for simulating the polygenic adaptation of recombining haploid populations using either new mutations or standing genetic variation. STUN assumes that populations adapt to sudden environmental changes by undergoing selection on a new fitness landscape. With pre-implemented fitness landscape models like Rough Mount Fuji, NK, Block, additive, and House-of-Cards, users can explore the effect of different levels of epistasis (ruggedness of the fitness landscape). Custom fitness landscapes and recombinatio

SUBMITTER: Amado A 

PROVIDER: S-EPMC10703519 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature