Consumption of Roasted Coffee Leads to Conjugated Metabolites of Atractyligenin in Human Plasma.

ABSTRACT: Roasted coffee contains atractyligenin-2-O-β-d-glucoside and 3'-O-β-d-glucosyl-2'-O-isovaleryl-2-O-β-d-glucosylatractyligenin, which are ingested with the brew. Known metabolites are atractyligenin, atractyligenin-19-O-β-d-glucuronide (M1), 2β-hydroxy-15-oxoatractylan-4α-carboxy-19-O-β-d-glucuronide (M2), and 2β-hydroxy-15-oxoatractylan-4α-carboxylic acid-2-O-β-d-glucuronide (M3), but the appearance and pharmacokinetic properties are unknown. Therefore, first time-resolved quantitative data of atractyligenin glycosides and their metabolites in plasma samples from a pilot human intervention study (n = 10) were acquired. None of the compounds were found in the control samples and before coffee consumption (t

SUBMITTER: Lang R 

PROVIDER: S-EPMC10722499 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature