Genetically determined alcohol consumption and cancer risk in Korea.

ABSTRACT:

Objectives

The purpose of this study was to determine the causal relationship between the genetically determined amount of alcohol consumption and the occurrence of major cancers.

Methods

The data used in this study were from 129,324 people selected from the Korean Cancer Prevention Study-II, the participants of which visited 18 health examination centers between 2004 and 2013. Cancer incidence was confirmed as of 2020 using data from the National Cancer Center. A genome-wide association study (GWAS) on alcohol consumption was performed using PLINK 2.0, and sex, age, chip type, and principal components were adjusted.

Results

From the GWAS, a genetic risk score for alcohol consumption was calculated and genetically determined alcohol consumption (GDAC) was estimated. G

SUBMITTER: Jung KJ 

PROVIDER: S-EPMC10728612 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature