A prognostic signature for lung adenocarcinoma by five genes associated with chemotherapy in lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is one of the most common subtypes of lung cancer. Finding prognostic biomarkers is helpful in stratifying LUAD patients with different prognosis.

Methods

We explored the correlation of LUAD prognosis and genes associated with chemotherapy in LUAD and obtained data of LUAD patients from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Drug sensitivity data were acquired from the Genomics of Drug Sensitivity in Cancer (GDSC) database. Differential and enrichment analyses were used to screen the target genes utilizing limma and "clusterProfiler" packages. Then univariate and LASSO Cox analyses were used to select the prognosis-related genes. Survival analysis was used to estimate the overall survival (OS) of diff

SUBMITTER: Li X 

PROVIDER: S-EPMC10730453 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature