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Viral and host factors drive a type 1 Epstein-Barr virus spontaneous lytic phenotype.

ABSTRACT:

Importance

Epstein-Barr virus (EBV) infects over 95% of adults worldwide. Given its connection to various cancers and autoimmune disorders, it is important to understand the mechanisms by which infection with EBV can lead to these diseases. In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. Because lytic replication of EBV has been linked to the pathogenesis of various diseases, these data could illuminate viral and host factors involved in this process.

SUBMITTER: Willard KA

PROVIDER: S-EPMC10746244 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Viral and host factors drive a type 1 Epstein-Barr virus spontaneous lytic phenotype.

Willard Katherine A KA Barry Ashley P AP Oduor Cliff I CI Ong'echa John Michael JM Bailey Jeffrey A JA Moormann Ann M AM Luftig Micah A MA

mBio 20231116 6

<h4>Importance</h4>Epstein-Barr virus (EBV) infects over 95% of adults worldwide. Given its connection to various cancers and autoimmune disorders, it is important to understand the mechanisms by which infection with EBV can lead to these diseases. In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. Because lytic replication of EBV has been linked to the pathogenesis of various diseases, these data could illumin ...[more]

PMID: 37971257

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