Psilocybin induces spatially constrained alterations in thalamic functional organizaton and connectivity.

ABSTRACT:

Background

Classic psychedelics, such as psilocybin and LSD, and other serotonin 2A receptor (5-HT_2AR) agonists evoke acute alterations in perception and cognition. Altered thalamocortical connectivity has been hypothesized to underlie these effects, which is supported by some functional MRI (fMRI) studies. These studies have treated the thalamus as a unitary structure, despite known differential 5-HT_2AR expression and functional specificity of different intrathalamic nuclei. Independent Component Analysis (ICA) has been previously used to identify reliable group-level functional subdivisions of the thalamus from resting-state fMRI (rsfMRI) data. We build on these efforts with a novel data-maximizing ICA-based approach to examine psilocybin-induced changes in

SUBMITTER: Gaddis A 

PROVIDER: S-EPMC10749714 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature