Complex repolarization dynamics in ex vivo human ventricles are independent of the restitution properties.

ABSTRACT:

Aims

The mechanisms of transition from regular rhythms to ventricular fibrillation (VF) are poorly understood. The concordant to discordant repolarization alternans pathway is extensively studied; however, despite its theoretical centrality, cannot guide ablation. We hypothesize that complex repolarization dynamics, i.e. oscillations in the repolarization phase of action potentials with periods over two of classic alternans, is a marker of electrically unstable substrate, and ablation of these areas has a stabilizing effect and may reduce the risk of VF. To prove the existence of higher-order periodicities in human hearts.

Methods and results

We performed optical mapping of explanted human hearts obtained from recipients of heart transplantation at the time of surgery. Signa

SUBMITTER: Iravanian S 

PROVIDER: S-EPMC10751849 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature