A Reinterpretation of the Relationship Between Persistent and Resurgent Sodium Currents.

ABSTRACT: The resurgent sodium current (I_NaR) activates on membrane repolarization, such as during the downstroke of neuronal action potentials. Due to its unique activation properties, I_NaR is thought to drive high rates of repetitive neuronal firing. However, I_NaR is often studied in combination with the persistent or non-inactivating portion of sodium currents (I_NaP). We used dynamic clamp to test how I_NaR and I_NaP individually affect repetitive firing in adult cerebellar Purkinje neurons from male and female mice. We learned I_NaR does not scale repetitive firing rates due to its rapid decay at subthreshold voltages, and that subthreshold I_NaP is critical in regulating neuronal firing rate. Adjustments to the

SUBMITTER: Brown SP 

PROVIDER: S-EPMC10769191 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature