Metabolic alterations in urine among the patients with severe fever with thrombocytopenia syndrome.

ABSTRACT:

Background

The pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) remained unclear. We aimed to profile the metabolic alterations in urine of SFTS patients and provide new evidence for its pathogenesis.

Methods

A case-control study was conducted in the 154th hospital in China. Totally 88 cases and 22 controls aged ≥ 18 years were enrolled. The cases were selected from laboratory-confirmed SFTS patients. The controls were selected among SFTSV-negative population. Those with diabetes, cancer, hepatitis and other sexually transmitted diseases were excluded in both groups. Fatal cases and survival cases were 1:1 matched. Inter-group differential metabolites and pathways were obtained, and the inter-group discrimination ability was evaluated.

Results

Trypto

SUBMITTER: Zhang SS 

PROVIDER: S-EPMC10775654 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature