Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study.

ABSTRACT:

Background

Stroke is the second leading cause of death worldwide, and observational studies have suggested a correlation between antioxidants and reduced stroke risk. However, it remains unclear whether causal relationships exist.

Methods

This study first performed a cross-sectional study of the association between the Composite Dietary Antioxidant Index (CDAI) and stroke using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Second, a two-sample univariable Mendelian Randomization (MR) was performed to analyze the causal effect of circulating levels of antioxidants on different subtypes of stroke.

Results

The cross-sectional study included a total of 24,892 participants representing more than 200 million US non-institutionalized resi

SUBMITTER: Chen R 

PROVIDER: S-EPMC10785483 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature