Biogenesis and delivery of extracellular vesicles: harnessing the power of EVs for diagnostics and therapeutics.

ABSTRACT: Extracellular vesicles (EVs) are membrane-enclosed particles secreted by a variety of cell types. These vesicles encapsulate a diverse range of molecules, including proteins, nucleic acids, lipids, metabolites, and even organelles derived from their parental cells. While EVs have emerged as crucial mediators of intercellular communication, they also hold immense potential as both biomarkers and therapeutic agents for numerous diseases. A thorough understanding of EV biogenesis is crucial for the development of EV-based diagnostic developments since the composition of EVs can reflect the health and disease status of the donor cell. Moreover, when EVs are taken up by target cells, they can exert profound effects on gene expression, signaling pathways, and cellular behavior, which makes these

SUBMITTER: Yu J 

PROVIDER: S-EPMC10791869 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature