A Genome-Wide Association Study of Serum Metabolite Profiles in Septic Shock Patients.

ABSTRACT:

Objectives

We sought to assess whether genetic associations with metabolite concentrations in septic shock patients could be used to identify pathways of potential importance for understanding sepsis pathophysiology.

Design

Retrospective multicenter cohort studies of septic shock patients.

Setting

All participants who were admitted to 27 participating hospital sites in three countries (Australia, New Zealand, and the United Kingdom) were eligible for inclusion.

Patients

Adult, critically ill, mechanically ventilated patients with septic shock (n = 230) who were a subset of the Adjunctive Corticosteroid Treatment in Critically Ill Patients with Septic Shock trial (ClinicalTrials.gov number: NCT01448109).

Interventions

None.

Measurements and main

SUBMITTER: Daubney ER 

PROVIDER: S-EPMC10796137 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature