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Heterogeneity and subtypes of CD4⁺ regulatory T cells: implications for tumor therapy.

ABSTRACT: In the conventional view, CD4⁺ regulatory T cell (T_reg) represents a subset of lymphocytes that involve the perception and negative regulation of the immune response. CD4⁺T_reg plays an important role in the maintenance of immune homeostasis and immune tolerance. However, recent studies have revealed that CD4⁺T_reg do not suppress the immune response in some diseases, but promote inflammatory injury or inhibit tissue remodeling, suggesting the functional heterogeneity of CD4⁺T_reg. Their involvement in tumor pathogenesis is more complex than previously understood. This article reviews the relevant research on the heterogeneity of CD4⁺T_reg, subtype classification, and their relationship with tumor therapy.

SUBMITTER: Lin H

PROVIDER: S-EPMC10796559 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Heterogeneity and subtypes of CD4+ regulatory T cells: implications for tumor therapy.

Lin Hanqing H Xu Yuanteng Y Lin Chang C

Frontiers in immunology 20240105

In the conventional view, CD4+ regulatory T cell (Treg) represents a subset of lymphocytes that involve the perception and negative regulation of the immune response. CD4+Treg plays an important role in the maintenance of immune homeostasis and immune tolerance. However, recent studies have revealed that CD4+Treg do not suppress the immune response in some diseases, but promote inflammatory injury or inhibit tissue remodeling, sug ...[more]

PMID: 38250084

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