Tetraspanin profiles of serum extracellular vesicles reflect functional limitations and pain perception in knee osteoarthritis.

ABSTRACT:

Background

Emerging evidence suggests that extracellular vesicles (EVs) can play roles in inflammatory processes and joint degradation in primary osteoarthritis (OA), a common age-associated joint disease. EV subpopulations express tetraspanins and platelet markers that may reflect OA pathogenesis. The present study investigated the associations between these EV surface markers and articular cartilage degradation, subjectively and objectively assessed pain, and functional limitations in primary knee OA (KOA).

Methods

Serum EVs were determined by high-sensitivity flow cytometry (large CD61⁺ EVs) and single particle interferometric reflectance imaging sensor (small CD41⁺, CD63⁺, CD81⁺, and CD9⁺ EVs) from end-stage KOA pati

SUBMITTER: Mustonen AM 

PROVIDER: S-EPMC10801950 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature