Quartet metabolite reference materials for inter-laboratory proficiency test and data integration of metabolomics profiling.

ABSTRACT:

Background

Various laboratory-developed metabolomic methods lead to big challenges in inter-laboratory comparability and effective integration of diverse datasets.

Results

As part of the Quartet Project, we establish a publicly available suite of four metabolite reference materials derived from B lymphoblastoid cell lines from a family of parents and monozygotic twin daughters. We generate comprehensive LC-MS-based metabolomic data from the Quartet reference materials using targeted and untargeted strategies in different laboratories. The Quartet multi-sample-based signal-to-noise ratio enables objective assessment of the reliability of intra-batch and cross-batch metabolomics profiling in detecting intrinsic biological differences among the four groups of samples. Significa

SUBMITTER: Zhang N 

PROVIDER: S-EPMC10809448 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature