Evaluation of the clinical relevance of the Biofire^© FilmArray pneumonia panel among hospitalized patients.

ABSTRACT:

Purpose

Panel PCR tests provide rapid pathogen identification. However, their diagnostic performance is unclear. We assessed the performance of the Biofire^© FilmArray pneumonia (PN)-panel against standard culture in broncho-alveolar lavage (BAL) samples.

Methods

Setting: University Hospital Basel (February 2019 to July 2020), including hospitalized patients with a BAL (± pneumonia). We determined sensitivity and specificity of the PN-panel against standard culture. Using univariate logistic regression, we calculated odds ratios (OR) for pneumonia according to PN-panel and culture status, stratifying by chronic pulmonary disease. We calculated ORs for pneumonia for different pathogens to estimate the clinical relevance.

Results

We included 840 adult patients

SUBMITTER: Sogaard KK 

PROVIDER: S-EPMC10810975 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature