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Reviving the Potential of Vermiculite-Based Adsorbents: Exceptional Ibuprofen Removal on Novel Amide-Containing Gemini Surfactants.

ABSTRACT: In this study, we introduce a novel series of gemini surfactants with amide groups (HDAB, HDAHD, and HDAPX) and use these surfactants to decorate sodium vermiculite (Na-Vt) for the adsorption of Ibuprofen (IBP) from wastewater. Exceptional IBP uptake on organo-vermiculites (organo-Vts) is obtained, with maximum adsorption capacities reaching 249.87, 342.21, and 460.15 mg/g for HDAB-Vt, HDAHD-Vt, and HDAPX-Vt (C₀ = 500 mg/L, modifier dosage = 0.2 CEC), respectively. The adsorption of IBP is well fitted by pseudo-second-order, intraparticle diffusion, and Freundlich isotherm models, verifying chemical adsorption processes with multilayer arrangement of IBP in organo-Vts. Thermodynamically, the removal of IBP on HDAHD-Vt is exothermic, while the endothermic nature aptly describes the adsorption process of HDAB-Vt and HDAPX-Vt. Moreover, organo-Vts can be stably regenerated in three cycles. Outstanding adsorption performance of organo-Vts is attributed to synergistic effects of the partition process and functional interaction, which are influenced by the steric hindrance and chain configuration of the modifier. A combined evaluation of adsorption tests and fitting calculations is employed to reveal the adsorption mechanism: (i) the incorporation of amides into the alkyl chain significantly enhances the utilization of the interlayer space in organo-Vts. (ii) Smaller steric hindrance and higher rigidity of the modifier spacer contribute to improved adsorption performance. The findings in this study rekindle interest in Vt-based adsorbents, which demonstrate comparable potential to other emerging adsorbents that are yet to be fully explored.

SUBMITTER: Hu X

PROVIDER: S-EPMC10831837 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Reviving the Potential of Vermiculite-Based Adsorbents: Exceptional Ibuprofen Removal on Novel Amide-Containing Gemini Surfactants.

Hu Xianqi X Ma Zhuang Z

ACS omega 20240118 4

In this study, we introduce a novel series of gemini surfactants with amide groups (HDAB, HDAHD, and HDAPX) and use these surfactants to decorate sodium vermiculite (Na-Vt) for the adsorption of Ibuprofen (IBP) from wastewater. Exceptional IBP uptake on organo-vermiculites (organo-Vts) is obtained, with maximum adsorption capacities reaching 249.87, 342.21, and 460.15 mg/g for HDAB-Vt, HDAHD-Vt, and HDAPX-Vt (<i>C</i><sub>0</sub> = 500 mg/L, modifier dosage = 0.2 CEC), respectively. The adsorpti ...[more]

PMID: 38313536

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Project description:BackgroundLipoplexes are non-viral vectors based on cationic lipids used to deliver DNA into cells, also known as lipofection. The positively charge of the hydrophilic head-group provides the cationic lipids the ability to condensate the negatively charged DNA into structured complexes. The polar head can carry a large variety of chemical groups including amines as well as guanidino or imidazole groups. In particular, gemini cationic lipids consist of two positive polar heads linked by a spacer with different length. As for the hydrophobic aliphatic chains, they can be unsaturated or saturated and are connected to the polar head-groups. Many other chemical components can be included in the formulation of lipoplexes to improve their transfection efficiency, which often relies on their structural features. Varying these components can drastically change the arrangement of DNA molecules within the lamellar, hexagonal or cubic phases that are provided by the lipid matrix. Lipofection is widely used to deliver genetic material in cell culture experiments but the simpler formulations exhibit major drawbacks related to low transfection, low specificity, low circulation half-life and toxicity when scaled up to in vivo experiments.ResultsSo far, we have explored in cell cultures the transfection ability of lipoplexes based on gemini cationic lipids that consist of two C16 alkyl chains and two imidazolium polar head-groups linked with a polyoxyethylene spacer, (C16Im)2(C4O). Here, PEGylated lipids have been introduced to the lipoplex formulation and the transgene expression of the Opa1 mitochondrial transmembrane protein in mice was assessed. The addition of PEG on the surface of the lipid mixed resulted in the formation of Ia3d bicontinuous cubic phases as determined by small angle X-ray scattering. After a single intramuscular administration, the cubic lipoplexes were accumulated in tissues with tight endothelial barriers such as brain, heart, and lungs for at least 48 h. The transgene expression of Opa1 in those organs was identified by western blotting or RNA expression analysis through quantitative polymerase chain reaction.ConclusionsThe expression reported here is sufficient in magnitude, duration and toxicity to consolidate the bicontinuous cubic structures formed by (C16Im)2(C4O)-based lipoplexes as valuable therapeutic agents in the field of gene delivery.

Project description:Effective removal of organic and inorganic impurities by adsorption technique requires the preparation of new materials characterized by low production costs, significant sorption capacity, and reduced toxicity, derived from natural and renewable sources. To address these challenges, new adsorbents have been developed in the form of polymer microspheres based on ethylene glycol dimethacrylate (EGDMA) and vinyl acetate (VA) (EGDMA/VA) containing starch (St) modified with boric acid (B) and dodecyl-S-thiuronium dodecylthioacetate (DiTDTA) for the removal of dyes: C.I. Basic Blue 3 (BB3) and C.I. Acid Green 16 (AG16) and heavy metal ions (M(II)): Cu(II), Ni(II), and Zn(II) from water and wastewater. The adsorbents were characterized by ATR/FT-IR, DSC, SEM, BET, EDS, and pHPZC methods. These analyses demonstrated the successful modification of microspheres and the increased thermal resistance resulting from the addition of the modified starch. The point of zero charge for EGDMA/VA was 7.75, and this value decreased with the addition of modified starch (pHPZC = 6.62 for EGDMA/VA-St/B and pHPZC = 5.42 for EGDMA/VA-St/DiTDTA). The largest specific surface areas (SBET) were observed for the EGDMA/VA microspheres (207 m2/g), and SBET value slightly decreases with the modified starch addition (184 and 169 m2/g) as a consquence of the pores stopping by the big starch molecules. The total pore volumes (Vtot) were found to be in the range from 0.227 to 0.233 cm3/g. These materials can be classified as mesoporous, with an average pore diameter (W) of approximately 55 Å (5.35-6.10 nm). The SEM and EDS analyses indicated that the EGDMA/VA microspheres are globular in shape with well-defined edges and contain 73.06% of carbon and 26.94% of oxygen. The microspheres containing modified starch exhibited a loss of smoothness with more irregular shape. The adsorption efficiency of dyes and heavy metal ions depends on the phases contact time, initial adsorbate concentration and the presence of competing electrolytes and surfactants. The equilibrium data were better fitted by the Freundlich isotherm model than by the Langmuir, Temkin, and Dubinin-Radushkevich models. The highest experimental adsorption capacities were observed for the BB3 dye which were equal to 193 mg/g, 190 mg/g, and 194 mg/g for EGDMA/VA, EGDMA/VA-St/B, EGDMA/VA-St/DiTDTA, respectively. The dyes and heavy metal ions were removed very rapidly and the time required to reach system equilibrium was below 20 min for M(II), 40 min for BB3, and 120 min for AG16. 50% v/v methanol and its mixture with 1 M HCl and NaCl for dyes and 1 M HCl for M(II) desorbed these impurities efficiently.

Dataset Information

Reviving the Potential of Vermiculite-Based Adsorbents: Exceptional Ibuprofen Removal on Novel Amide-Containing Gemini Surfactants.

Publications

Reviving the Potential of Vermiculite-Based Adsorbents: Exceptional Ibuprofen Removal on Novel Amide-Containing Gemini Surfactants.

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