Using molecular characteristics to distinguish multiple primary lung cancers and intrapulmonary metastases.

ABSTRACT:

Objectives

Multiple lung cancers may present as multiple primary lung cancers (MPLC) or intrapulmonary metastasis (IPM) with variations in clinical stage, treatment, and prognosis. However, the existing differentiation criteria based on histology do not fully meet the clinical needs. Next-generation sequencing (NGS) may play an important role in assisting the identification of different pathologies. Here, we extended the relevant data by combining histology and NGS to develop detailed identification criteria for MPLC and IPM.

Materials and methods

Patients with lung cancer (each patient had ≥2 tumors) were enrolled in the training (n = 22) and validation (n = 13) cohorts. Genomic profiles obtained from 450-gene-targeted NGS were analyzed, and the new criteria w

SUBMITTER: Li Z 

PROVIDER: S-EPMC10838092 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature