Albumin versus saline infusion for sepsis-related peripheral tissue hypoperfusion: a proof-of-concept prospective study.

ABSTRACT:

Background

Albumin has potential endothelial protective effects through antioxidant and anti-inflammatory properties. However, the effect of albumin on peripheral tissue perfusion in human sepsis remains poorly known.

Methods

Bi-centric prospective study included patients with sepsis with or without shock and prolonged CRT > 3 s despite initial resuscitation. Clinicians in charge of the patients were free to infuse either saline 500 mL or human serum albumin 20% 100 mL over 15 min. Global hemodynamic parameters as well as peripheral tissue perfusion were analyzed after 1 (H1) and 4 h (H4). The primary endpoint was CRT normalization (< 3 s) at H1.

Results

62 patients were screened, and 50 patients (13 sepsis and 37 septic shock) were included, 21 in the saline group an

SUBMITTER: Gabarre P 

PROVIDER: S-EPMC10848485 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature