Sex-Dependent Effects of Chronic Circadian Disruption in AβPP/PS1 Mice.

ABSTRACT:

Background

Chronic disruption of the circadian timing system, often reflected as a loss of restful sleep, also includes myriad other pathophysiological effects.

Objective

The current study examined how chronic circadian disruption (CD) could contribute to pathology and rate of progression in the AβPP/PS1 mouse model of Alzheimer's disease (AD).

Methods

A chronic CD was imposed until animals reached 6 or 12 months of age in AβPP/PS1 and C57BL/6J control mice. Home cage activity was monitored for a period of 3-4 weeks prior to the endpoint along with a single timepoint measure of glucose sensitivity. To assess long term effects of CD on the AD phenotype, animals were re-entrained to a no disruption (ND) schedule just prior to the endpoint, after which a Morris water maz

SUBMITTER: Britz J 

PROVIDER: S-EPMC10860643 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature