Pectolinarigenin regulates the tumor-associated proteins in AGS-xenograft BALB/c nude mice.

ABSTRACT:

Background

Pectolinarigenin (PEC) is a flavone extracted from Cirsium, and because it has anti-inflammatory properties, anti-cancer research is also being conducted. The objective of this work was to find out if PEC is involved in tumor control and which pathways it regulates in vivo and in vitro.

Methods

AGS cell lines were xenografted into BALB/c nude mice to create tumors, and PEC was administered intraperitoneally to see if it was involved in tumor control. Once animal testing was completed, tumor proteins were isolated and identified using LC-MS analysis, and gene ontology of the found proteins was performed.

Results

Body weight and hematological measurements on the xenograft mice model demonstrated that PEC was not harmful to non-cancerous cells. We found 582 pr

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC10869406 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature