S-EPMC10869406 - Pectolinarigenin regulates the tumor-associated proteins in AGS-xenograft BALB/c nude mice. - OmicsDI

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Pectolinarigenin regulates the tumor-associated proteins in AGS-xenograft BALB/c nude mice.

ABSTRACT:

Background

Pectolinarigenin (PEC) is a flavone extracted from Cirsium, and because it has anti-inflammatory properties, anti-cancer research is also being conducted. The objective of this work was to find out if PEC is involved in tumor control and which pathways it regulates in vivo and in vitro.

Methods

AGS cell lines were xenografted into BALB/c nude mice to create tumors, and PEC was administered intraperitoneally to see if it was involved in tumor control. Once animal testing was completed, tumor proteins were isolated and identified using LC-MS analysis, and gene ontology of the found proteins was performed.

Results

Body weight and hematological measurements on the xenograft mice model demonstrated that PEC was not harmful to non-cancerous cells. We found 582 proteins in tumor tissue linked to biological reactions such as carcinogenesis and cell death signaling. PEC regulated 6 out of 582 proteins in vivo and in vitro in the same way.

Conclusion

Our findings suggested that PEC therapy may inhibit tumor development in gastric cancer (GC), and proteomic research gives fundamental information about proteins that may have great promise as new therapeutic targets in GC.

SUBMITTER: Lee HJ

PROVIDER: S-EPMC10869406 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Publications

Pectolinarigenin regulates the tumor-associated proteins in AGS-xenograft BALB/c nude mice.

Lee Ho Jeong HJ Kwon Young Sang YS Lee Ju Hong JH Moon Yeon Gyu YG Choi Jungil J Hyun Moonjung M Tak Tae Kil TK Kim Je-Hein JH Heo Jeong Doo JD

Molecular biology reports 20240216 1

<h4>Background</h4>Pectolinarigenin (PEC) is a flavone extracted from Cirsium, and because it has anti-inflammatory properties, anti-cancer research is also being conducted. The objective of this work was to find out if PEC is involved in tumor control and which pathways it regulates in vivo and in vitro.<h4>Methods</h4>AGS cell lines were xenografted into BALB/c nude mice to create tumors, and PEC was administered intraperitoneally to see if it was involved in tumor control. Once animal testing ...[more]

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