The effect of ulinastatin on acute kidney injury in patients undergoing off-pump cardiac bypass surgery.

ABSTRACT:

Background

Ulinastatin, an anti-inflammatory and antioxidant trypsin inhibitor, has shown potential in mitigating acute kidney injury (AKI) and reducing serum creatinine levels after various surgeries. This retrospective study aimed to evaluate the effects of ulinastatin on AKI in patients undergoing off-pump coronary artery bypass (OPCAB) surgery.

Methods

We hypothesized that the administration of ulinastatin could prevent AKI in OPCAB. Electrical medical records were reviewed to identify OPCAB patients between January 2015 and June 2020. The utilization of ulinastatin was randomly determined and applied during this period. Acute kidney injury was defined according to the KDIGO guideline, and its incidence was compared between the ulinastatin administration group and the co

SUBMITTER: Park SJ 

PROVIDER: S-EPMC10870510 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature