Air pollution and epigenetic aging among Black and White women in the US.

ABSTRACT:

Background

DNA methylation-based measures of biological aging have been associated with air pollution and may link pollutant exposures to aging-related health outcomes. However, evidence is inconsistent and there is little information for Black women.

Objective

We examined associations of ambient particulate matter <2.5 μm and <10 μm in diameter (PM_2.5 and PM₁₀) and nitrogen dioxide (NO₂) with DNA methylation, including epigenetic aging and individual CpG sites, and evaluated whether associations differ between Black and non-Hispanic White (NHW) women.

Methods

Validated models were used to estimate annual average outdoor residential exposure to PM_2.5, PM₁₀, and NO₂ in a sample of self-identified Black (

SUBMITTER: Koenigsberg SH 

PROVIDER: S-EPMC10872847 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature