Eomesodermin-expressing CD4+ Th cells and association with pregnancy in multiple sclerosis.

ABSTRACT:

Background

Pregnancy in patients with multiple sclerosis (MS) is accompanied by a decline of relapse activity with increased risk of relapses 3 months post-partum, for unknown reasons. Eomesodermin⁺ T-helper cells (Eomes⁺ Th cells) are known to mediate neuroinflammation and disease progression in MS and are induced by prolactin-secreting cells.

Objectives

Here, investigated immune cell alterations and the pathophysiological role of Eomes⁺ Th cells for disease activity during pregnancy and post-partum in MS.

Methods

We enrolled n = 81 pregnant patients with relapsing-remitting MS (RRMS), n = 27 post-partum RRMS and n = 26 female RRMS control patients under the umbrella of the German Multiple Sclerosis and Pregnancy

SUBMITTER: Faissner S 

PROVIDER: S-EPMC10874138 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature