Integrated analysis of differentially expressed genes and miRNA expression profiles in dilated cardiomyopathy.

ABSTRACT:

Background

Although dilated cardiomyopathy (DCM) is a prevalent form of cardiomyopathy, the molecular mechanisms underlying its pathogenesis and progression remain poorly understood. It is possible to identify and validate DCM-associated genes, pathways, and miRNAs using bioinformatics analysis coupled with clinical validation methods.

Methods

Our analysis was performed using 3 mRNA datasets and 1 miRNA database. We employed several approaches, including gene ontology (GO) analysis, KEGG pathway enrichment analysis, protein-protein interaction networks analysis, and analysis of hub genes to identify critical genes and pathways linked to DCM. We constructed a regulatory network for DCM that involves interactions between miRNAs and mRNAs. We also validated the differently expr

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10878877 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature