Carbapenem-resistant Enterobacterales in Children at 18 US Health Care System Study Sites: Clinical and Molecular Epidemiology From a Prospective Multicenter Cohort Study.

ABSTRACT:

Background

Carbapenem-resistant Enterobacterales (CRE) are an urgent public health threat in the United States.

Objective

Describe the clinical and molecular epidemiology of CRE in a multicenter pediatric cohort.

Methods

CRACKLE-1 and CRACKLE-2 are prospective cohort studies with consecutive enrollment of hospitalized patients with CRE infection or colonization between 24 December 2011 and 31 August 2017. Patients younger than age 18 years and enrolled in the CRACKLE studies were included in this analysis. Clinical data were obtained from the electronic health record. Carbapenemase genes were detected using polymerase chain reaction and whole-genome sequencing.

Results

Fifty-one children were identified at 18 healthcare system study sites representing al

SUBMITTER: Fisher M 

PROVIDER: S-EPMC10883725 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature