Chemotherapy-induced microbiota exacerbates the toxicity of chemotherapy through the suppression of interleukin-10 from macrophages.

ABSTRACT: The gut microbiota has been shown to influence the efficacy and toxicity of chemotherapy, thereby affecting treatment outcomes. Understanding the mechanism by which microbiota affects chemotherapeutic toxicity would have a profound impact on cancer management. In this study, we report that fecal microbiota transplantation from oxaliplatin-exposed mice promotes toxicity in recipient mice. Splenic RNA sequencing and macrophage depletion experiment showed that the microbiota-induced toxicity of oxaliplatin in mice was dependent on macrophages. Furthermore, oxaliplatin-mediated toxicity was exacerbated in Il10^-/- mice, but not attenuated in Rag1^-/- mice. Adoptive transfer of macrophage into Il10^-/- mice confirmed the ro

SUBMITTER: He Z 

PROVIDER: S-EPMC10896127 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature