Comparative genomics between matched solid and lepidic portions of semi-solid lung adenocarcinomas.

ABSTRACT:

Background

Genetic changes that drive the transition from lepidic to invasive cancer development within a radiographic ground glass or semi-solid lung lesion (SSL) are not well understood. Biomarkers to predict the transition to solid, invasive cancer within SSL are needed.

Methods

Patients with surgically resected SSL were identified retrospectively from a surgical database. Clinical characteristics and survival were compared between stage I SSL (n = 65) and solid adenocarcinomas (n = 120) resected during the same time period. Areas of normal lung, in situ lepidic, and invasive solid tumor were microdissected from within the same SSL specimens and next generation sequencing (NGS) and Affymetrix microarray of gene expression were performed.

Results

There were more nev

SUBMITTER: Woodard GA 

PROVIDER: S-EPMC10900430 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature