HIV-1 proviral DNA in purified peripheral blood CD34⁺ stem and progenitor cells in individuals with long-term HAART; paving the way to HIV gene therapy.

ABSTRACT: Human immunodeficiency virus (HIV)-1 infection is an important public health problem worldwide. After primary HIV-1 infection, transcribed HIV-1 DNA is integrated into the host genome, serving as a reservoir of the virus and hindering a definite cure. Although highly active antiretroviral therapy suppresses active viral replication, resulting in undetectable levels of HIV RNA in the blood, a viral rebound can be detected after a few weeks of treatment interruption. This supports the concept that there is a stable HIV-1 reservoir in people living with HIV-1. Recently, a few individuals with HIV infection were reported to be probably cured by hematopoietic stem transplantation (HSCT). The underlying mechanism for this success involved transfusion of uninfected hematopoietic stem and progenit

SUBMITTER: Tassaneetrithep B 

PROVIDER: S-EPMC10906414 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature