Sex-specific genetic architecture of late-life memory performance.

ABSTRACT:

Background

Women demonstrate a memory advantage when cognitively healthy yet lose this advantage to men in Alzheimer's disease. However, the genetic underpinnings of this sex difference in memory performance remain unclear.

Methods

We conducted the largest sex-aware genetic study on late-life memory to date (N_males  = 11,942; N_females  = 15,641). Leveraging harmonized memory composite scores from four cohorts of cognitive aging and AD, we performed sex-stratified and sex-interaction genome-wide association studies in 24,216 non-Hispanic White and 3367 non-Hispanic Black participants.

Results

We identified three sex-specific loci (rs67099044-CBLN2, rs719070-SCHIP1/IQCJ-SCHIP), including an X-chromosome locus (rs5935633-EGL6/TCEANC/OFD1), that asso

SUBMITTER: Eissman JM 

PROVIDER: S-EPMC10917043 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature