Tumor-infiltrating mast cells stimulate ICOS⁺ regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression.

ABSTRACT:

Introduction

In solid tumors, regulatory T cell (Treg) and mast cell perform different roles depending on the microenvironment. Nevertheless, mast cell and Treg-mediated interactions in gastric cancer (GC) are unclear, as are their regulation, function, and clinical significance.

Objective

The present study demonstrated the mechanism of tumor-infiltrating mast cells stimulating ICOS⁺ regulatory T cells via the IL-33/IL-2 axis to promote the growth of gastric cancer.

Methods

Analyses of 98 patients with GC were conducted to examine mast cell counts, ICOS⁺ Tregs, and the levels of IL-33 or IL-2. Isolated ICOS⁺ Treg and CD8⁺ T cell were stimulated, cultured and tested for their functional abilities in vitro and in vivo.

Resu

SUBMITTER: Lv Y 

PROVIDER: S-EPMC10918354 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature