Senescence-related genes analysis in breast cancer reveals the immune microenvironment and implications for immunotherapy.

ABSTRACT: Despite the advent of precision therapy for breast cancer (BRCA) treatment, some individuals are still unable to benefit from it and have poor survival prospects as a result of the disease's high heterogeneity. Cell senescence plays a crucial role in the tumorigenesis, progression, and immune regulation of cancer and has a major impact on the tumor microenvironment. To find new treatment strategies, we aimed to investigate the potential significance of cell senescence in BRCA prognosis and immunotherapy. We created a 9-gene senescence-related signature. We evaluated the predictive power and the role of signatures in the immune microenvironment and infiltration. In vitro tests were used to validate the expression and function of the distinctive critical gene ACTC1. Our risk signature

SUBMITTER: Zhong H 

PROVIDER: S-EPMC10929821 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature