Feasibility of dynamic T₂ *-based oxygen-enhanced lung MRI at 3T.

ABSTRACT:

Purpose

To demonstrate proof-of-concept of a T₂ *-sensitized oxygen-enhanced MRI (OE-MRI) method at 3T by assessing signal characteristics, repeatability, and reproducibility of dynamic lung OE-MRI metrics in healthy volunteers.

Methods

We performed sequence-specific simulations for protocol optimisation and acquired free-breathing OE-MRI data from 16 healthy subjects using a dual-echo RF-spoiled gradient echo approach at 3T across two institutions. Non-linear registration and tissue density correction were applied. Derived metrics included percent signal enhancement (PSE), ∆R₂ * and wash-in time normalized for breathing rate (τ-nBR). Inter-scanner reproducibility and intra-scanner repeatability were evaluated using intra-class correlation coefficient (

SUBMITTER: Kim M 

PROVIDER: S-EPMC10952203 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature