CD4⁺ T cell mitochondrial genotype in Multiple Sclerosis: a cross-sectional and longitudinal analysis.

ABSTRACT: Multiple Sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS), with a largely unknown etiology, where mitochondrial dysfunction likely contributes to neuroaxonal loss and brain atrophy. Mirroring the CNS, peripheral immune cells from patients with MS, particularly CD4⁺ T cells, show inappropriate mitochondrial phenotypes and/or oxidative phosphorylation (OxPhos) insufficiency, with a still unknown contribution of mitochondrial DNA (mtDNA). We hypothesized that mitochondrial genotype in CD4⁺ T cells might influence MS disease activity and progression. Thus, we performed a retrospective cross-sectional and longitudinal study on patients with a recent diagnosis of either Clinically Isolated Syndrome (CIS) or Relapsing-Remitting

SUBMITTER: Cortes-Figueiredo F 

PROVIDER: S-EPMC10980703 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature