Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns.

ABSTRACT:

Introduction

We sought to determine structural magnetic resonance imaging (MRI) characteristics across subgroups defined based on relative cognitive domain impairments using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to compare cognitively defined to imaging-defined subgroups.

Methods

We used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123 unknown amyloid status) and 118 amyloid-negative controls. We used voxel-based morphometry to compare gray matter volume (GMV) for each group compared to controls and to AD-Memory.

Results

There was pronounced bilateral lower medial temporal lobe atrophy with relative cortical sparing for AD-Memory, lower left hemisphere GMV for AD-Language, anterior lower GMV for AD-Executive,

SUBMITTER: Crane PK 

PROVIDER: S-EPMC10984445 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature